De Lisle, who is also rock critic of the Mail on Sunday, steps up from his previous role as deputy editor for the magazine.
He replaces Edward Carr, who becomes editorial director for the title, as well as maintaining his role as business affairs editor of The Economist.
De Lisle has also worked for The Times, The Independent on Sunday and the Daily Telegraph.
Commenting on his new role, De Lisle said: "Intelligent Life has rapidly established itself as a distinctive presence on the news stand, offering lifestyle with substance, mixing leading freelance contributors with the deep well of talent at The Economist, and adding great photography and illustration.
"It's a title people really want to work for. I've really enjoyed being deputy to Ed Carr and I'm excited to have the chance to carry on his good work."
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