Huffington Post is working in partnership with the publisher of La Repubblica, Gruppo Espresso, to produce the new site, edited by Italian journalist Lucia Annunziata.
The Huffington Post's UK edition celebrated its first birthday in July, and other recent launches include a Spanish edition in partnership with El Pais in June this year, and a French edition in October last year, in partnership with Le Monde and Les Nouvelles Editions Independantes.
According to the Post its UK edition recorded more than four million unique visitors for the first time in August this year, said to be based on figures from comScore.
In a post announcing the launch of the Italian version of the site, president and editor-in-chief of the AOL Huffington Post Media Group, Arianna Huffington said "we'll be using all the tools at our disposal to tell the most important - and most entertaining - stories of our time".
"And, just as important, help Italians tell their stories themselves. And since Italy's 35.8 million Internet users make up nearly 59 per cent of the population, it's our hope that L'HuffPost will help expand the conversation at a time when Italians are looking to each other and their communities - both online and offline - for the empathy, ingenuity and creativity that will lead to the real solutions the country needs."