The week-long blog involving eight Trinity papers, including the Liverpool Echo and Liverpool Daily Post, and LDPBusiness.co.uk will document the first week of a new centralised editorial hub.
News conferences and morning meetings will be streamed to the liveblog from 7am on Monday.
Video and images taken during the restructuring of the newsroom will also be posted and journalists at the titles will contribute directly to the blog and via Twitter accounts.
"This is a major change for us and we wanted to mark what we were doing, tell people about it and give them the opportunity to see it, ask us questions and tell us what they think," said Alistair Machray, editor-in-chief.
[Follow the liveblog on Journalism.co.uk at this link]
Trinity's Liverpool titles have previously used liveblogging to cover 'a day in the life' of the Post's newsroom and the Rhys Jones murder trial.
Regional titles from the group also jointly used CoverItLive last year to report on the UK's financial crisis.
"We aren't afraid to experiment and try radical new methods of newsgathering and storytelling - we think this is one of the most exciting developments for regional newspapers in a while; what we are saying is that we know our industry is changing and we're up to the challenge of changing with it," added Machray.
"We can learn from our readers and through telling them what we are doing, inviting them into our new operation, we think they can learn more about us."
Newsdesks at the Echo and Post previously experimented with integration, but the new multimedia hub will see journalists from Trinity's Merseyside division working across all weekly and daily titles in the region.
New digital appointments have been made as part of the restructure, but 43 editorial staff at the titles are expected to lose their jobs.
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